• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

使用3-溴-4-(吲哚-1-基)马来酰亚胺支架合成6H-吡咯并[3',4':2,3][1,4]二氮杂卓并[6,7,1-hi]吲哚-8,10(7H,9H)-二酮

Synthesis of 6H-pyrrolo[3',4':2,3][1,4]diazepino[6,7,1-hi]indole-8,10(7H,9H)-diones using 3-bromo-4-(indol-1-yl)maleimide scaffold.

作者信息

Lakatosh Sergey A, Luzikov Yuri N, Preobrazhenskaya Maria N

机构信息

Gause Institute of New Antibiotics, Russian Academy of Medical Sciences, B. Pirogovskaya 11, Moscow 119021, Russia.

出版信息

Org Biomol Chem. 2003 Mar 7;1(5):826-33. doi: 10.1039/b211163b.

DOI:10.1039/b211163b
PMID:12929367
Abstract

Series of 3-arylalkyl- or 3-alkylamino-4-(indol-1-yl)maleimides and bis(indol-1-yl)maleimides were synthesised. The cyclization of the 3-substituted 4-(indol-1-yl)maleimides under the action of acids resulted in the formation of diazepine[1,4] derivatives with indoline and maleimide nuclei annelated. These compounds readily produced the corresponding indolomaleimidodiazepines[1,4] after dehydrogenation.

摘要

合成了一系列3-芳基烷基-或3-烷基氨基-4-(吲哚-1-基)马来酰亚胺和双(吲哚-1-基)马来酰亚胺。3-取代的4-(吲哚-1-基)马来酰亚胺在酸的作用下环化，形成了稠合有吲哚啉和马来酰亚胺环的二氮杂卓[1,4]衍生物。这些化合物脱氢后很容易生成相应的吲哚马来酰亚胺并二氮杂卓[1,4]。

相似文献

1
Synthesis of 6H-pyrrolo[3',4':2,3][1,4]diazepino[6,7,1-hi]indole-8,10(7H,9H)-diones using 3-bromo-4-(indol-1-yl)maleimide scaffold.使用3-溴-4-(吲哚-1-基)马来酰亚胺支架合成6H-吡咯并[3',4':2,3][1,4]二氮杂卓并[6,7,1-hi]吲哚-8,10(7H,9H)-二酮
Org Biomol Chem. 2003 Mar 7;1(5):826-33. doi: 10.1039/b211163b.
2
Search for inhibitors of bacterial and human protein kinases among derivatives of diazepines[1,4] annelated with maleimide and indole cycles.在与马来酰亚胺和吲哚环稠合的二氮杂䓬[1,4]衍生物中寻找细菌和人类蛋白激酶的抑制剂。
J Med Chem. 2008 Dec 25;51(24):7731-6. doi: 10.1021/jm800758s.
3
Synthesis and biological evaluation of achiral indole-substituted titanocene dichloride derivatives.非手性吲哚取代二氯二茂钛衍生物的合成与生物学评价
Int J Med Chem. 2012;2012:905981. doi: 10.1155/2012/905981. Epub 2012 Jun 12.
4
The development of potent and selective bisarylmaleimide GSK3 inhibitors.强效和选择性双芳基马来酰亚胺糖原合成酶激酶3抑制剂的研发
Bioorg Med Chem Lett. 2005 Feb 15;15(4):899-903. doi: 10.1016/j.bmcl.2004.12.063.
5
Metabolism of the Tobacco Carcinogen 2-Amino-9H-pyrido[2,3-b]indole (AαC) in Primary Human Hepatocytes.烟草致癌物2-氨基-9H-吡啶并[2,3-b]吲哚（AαC）在原代人肝细胞中的代谢
Chem Res Toxicol. 2017 Feb 20;30(2):657-668. doi: 10.1021/acs.chemrestox.6b00394. Epub 2016 Dec 15.
6
Efficient synthesis of polyfunctionalized carbazoles and pyrrolo[3,4]carbazoles via domino Diels-Alder reaction.通过多米诺狄尔斯-阿尔德反应高效合成多官能化咔唑和吡咯并[3,4]咔唑。
Beilstein J Org Chem. 2021 Sep 16;17:2425-2432. doi: 10.3762/bjoc.17.159. eCollection 2021.
7
Synthesis and preliminary characterization of radioiodinated benzofuran-3-yl-(indol-3-yl)maleimide derivatives as potential SPECT imaging probes for the detection of glycogen synthase kinase-3β (GSK-3β) in the brain.放射性碘化苯并呋喃-3-基-（吲哚-3-基）马来酰亚胺衍生物的合成与初步表征：作为用于检测脑中糖原合酶激酶-3β（GSK-3β）的潜在单光子发射计算机断层扫描（SPECT）成像探针
J Labelled Comp Radiopharm. 2016 Jun 30;59(8):317-21. doi: 10.1002/jlcr.3404. Epub 2016 Apr 29.
8
Synthesis of some new hydrazone derivatives as biologically active agents.一些新型腙衍生物作为生物活性剂的合成
Arzneimittelforschung. 1986 May;36(5):790-3. doi: 10.1002/chin.198642210.
9
Rapid access to N-(indol-2-yl)amides and N-(indol-3-yl)amides as unexplored pharmacophores.快速获取作为未开发药效基团的N-（吲哚-2-基）酰胺和N-（吲哚-3-基）酰胺。
Org Biomol Chem. 2017 Jan 18;15(3):576-580. doi: 10.1039/c6ob02622b.
10
Marine Inspired 2-(5-Halo-1H-indol-3-yl)-N,N-dimethylethanamines as Modulators of Serotonin Receptors: An Example Illustrating the Power of Bromine as Part of the Uniquely Marine Chemical Space.受海洋启发的2-(5-卤代-1H-吲哚-3-基)-N,N-二甲基乙胺作为5-羟色胺受体调节剂：一个说明溴作为独特海洋化学空间一部分的强大作用的例子。
Mar Drugs. 2017 Aug 9;15(8):248. doi: 10.3390/md15080248.

引用本文的文献

1
Discovery of intermolecular cascade annulation for dihydrobenzo[][1,8]naphthyridine-ylidene-pyrrolidinetriones.二氢苯并[][1,8]萘啶亚基-吡咯烷三酮分子间级联环化反应的发现
Chem Sci. 2025 Jan 28;16(9):4119-4126. doi: 10.1039/d4sc07999j. eCollection 2025 Feb 26.
2
Synthesis of 1,3,5-Triazepines and Benzo[][1,3,5]triazepines and Their Biological Activity: Recent Advances and New Approaches.1,3,5-三嗪和苯并[][1,3,5]三嗪的合成及其生物活性：最新进展和新方法。
Molecules. 2024 Jan 29;29(3):632. doi: 10.3390/molecules29030632.
3
New spectrofluorimetric methods for determination of melatonin in the presence of N-{2-[1-({3-[2-(acetylamino)ethyl]-5-methoxy-1H-indol-2-yl}methyl)-5-methoxy-1H-indol-3-yl]- ethyl}acetamide: a contaminant in commercial melatonin preparations.
在存在N-{2-[1-({3-[2-(乙酰氨基)乙基]-5-甲氧基-1H-吲哚-2-基}甲基)-5-甲氧基-1H-吲哚-3-基]-乙基}乙酰胺的情况下测定褪黑素的新荧光分光光度法：一种商业褪黑素制剂中的污染物。
Chem Cent J. 2012 May 2;6(1):36. doi: 10.1186/1752-153X-6-36.
4
Synthesis and cyclometalation of a pyrido[3,2-e]-2,10b-diaza-cyclopenta[c]fluorene-1,3-dione scaffold.吡啶并[3,2-e]-2,10b-二氮杂环戊二烯并[c]芴-1,3-二酮骨架的合成与环金属化
Tetrahedron Lett. 2006 Dec 11;47(50):8877-8880. doi: 10.1016/j.tetlet.2006.10.054.