Sato Itaru, Ohno Atsushi, Aoyama Yohei, Kasahara Toshinari, Soai Kenso
Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo, 162-8601, Japan.
Org Biomol Chem. 2003 Jan 21;1(2):244-6. doi: 10.1039/b209520n.
Chiral hydrocarbon [2.2]paracyclophanes act as chiral initiators in asymmetric autocatalysis in the addition of diisopropylzinc to pyrimidine-5-carbaldehyde and give highly enantiomerically enriched 5-pyrimidyl alkanol with a reversed sense of the enantioselectivity to that of other [2.2]paracyclophanes with heteroatoms.
手性烃[2.2]对环芳烷在二异丙基锌加成到嘧啶-5-甲醛的不对称自催化中作为手性引发剂，并生成对映体高度富集的5-嘧啶基烷醇，其对映选择性的方向与其他含杂原子的[2.2]对环芳烷相反。
