手性烃[2.2]对环芳烷诱导的不对称自催化作用。

Asymmetric autocatalysis induced by chiral hydrocarbon [2.2]paracyclophanes.

作者信息

Sato Itaru, Ohno Atsushi, Aoyama Yohei, Kasahara Toshinari, Soai Kenso

机构信息

Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo, 162-8601, Japan.

出版信息

Org Biomol Chem. 2003 Jan 21;1(2):244-6. doi: 10.1039/b209520n.

DOI:10.1039/b209520n

PMID:12929417

Abstract

Chiral hydrocarbon [2.2]paracyclophanes act as chiral initiators in asymmetric autocatalysis in the addition of diisopropylzinc to pyrimidine-5-carbaldehyde and give highly enantiomerically enriched 5-pyrimidyl alkanol with a reversed sense of the enantioselectivity to that of other [2.2]paracyclophanes with heteroatoms.

摘要

手性烃[2.2]对环芳烷在二异丙基锌加成到嘧啶-5-甲醛的不对称自催化中作为手性引发剂，并生成对映体高度富集的5-嘧啶基烷醇，其对映选择性的方向与其他含杂原子的[2.2]对环芳烷相反。