Tanida Mamoru, Nagai Katsuya, Kaneko Hidekazu
Division of Protein Metabolism, Institute for Protein Research, Osaka University, Osaka, 565-0871, Japan.
In Vivo. 2003 May-Jun;17(3):213-7.
Leptin produced in white adipose tissue activates sympathetic nerve activity via the ventromedial hypothalamus (VMH) within the central nervous system (CNS). Using an electrophysiological technique, we investigated whether direct microinjection of leptin into the VMH elevates renal sympathetic nerve activity (RSNA) and blood pressure (BP) in anesthetized rats. Microinjection of leptin (100 ng/microL) into the VMH caused significant activation of RSNA from 25 minutes after administration but no affect on BP. We concluded that leptin-induced elevation of RSNA is mediated via the VMH or its vicinity within the CNS.
白色脂肪组织产生的瘦素通过中枢神经系统（CNS）内的腹内侧下丘脑（VMH）激活交感神经活动。我们使用电生理技术，研究了向VMH直接微量注射瘦素是否会提高麻醉大鼠的肾交感神经活动（RSNA）和血压（BP）。向VMH微量注射瘦素（100 ng/μL）会在给药后25分钟引起RSNA显著激活，但对BP无影响。我们得出结论，瘦素诱导的RSNA升高是通过CNS内的VMH或其附近区域介导的。
