从裙带菜孢子叶中提取的裙带菜岩藻聚糖的抗肿瘤活性和免疫反应。
Antitumor activity and immune response of Mekabu fucoidan extracted from Sporophyll of Undaria pinnatifida.
作者信息
Maruyama Hiroko, Tamauchi Hidekazu, Hashimoto Minoru, Nakano Takahisa
机构信息
Department of Pathology, School of Allied Health Sciences, Kitasato University, Kitasato 1-15-1, Sagamihara, Kanagawa 228-8555, Japan.
出版信息
In Vivo. 2003 May-Jun;17(3):245-9.
BACKGROUND
We showed that fucoidan, extracted from dietary seaweed, could inhibit tumor growth. However, the mechanism of Mekabu (Sporophyll of Undaria pinnatifida) fucoidan antitumor activity and how it enhances the immune response remains unknown.
MATERIALS AND METHODS
We examined the effect of Mekabu fucoidan in P-388 tumor-bearing mice and in T cell-mediated NK cell activity in normal mice.
RESULTS
The survival of mice was prolonged when Mekabu fucoidan was administered for 4 days before tumor cell inoculation, compared with non-treated mice. Fucoidan significantly enhanced the cytolytic activity of NK cells and increased the amount of IFN-gamma produced by T cells up to about 2-fold compared with non-treated mice.
CONCLUSION
The anti-tumor effect of Mekabu fucoidan appears to be mediated by IFN-gamma-activated NK cells.
背景
我们发现，从食用海藻中提取的岩藻依聚糖能够抑制肿瘤生长。然而，裙带菜（裙带菜的孢子叶）岩藻依聚糖的抗肿瘤活性机制以及它如何增强免疫反应仍然未知。
材料与方法
我们检测了裙带菜岩藻依聚糖对荷P-388肿瘤小鼠的影响以及对正常小鼠T细胞介导的自然杀伤细胞（NK细胞）活性的影响。
结果
与未处理的小鼠相比，在接种肿瘤细胞前4天给予裙带菜岩藻依聚糖，小鼠的生存期延长。与未处理的小鼠相比，岩藻依聚糖显著增强了NK细胞的细胞溶解活性，并使T细胞产生的γ干扰素量增加了约2倍。
结论
裙带菜岩藻依聚糖的抗肿瘤作用似乎是由γ干扰素激活的NK细胞介导的。
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