盐酸表柔比星（EPI）联合醋酸甲羟孕酮（MPA）预处理对移植于雌性C3H/He小鼠体内的FM3A乳腺癌细胞的影响。
The effects of epirubicin hydrochloride (EPI) plus pretreatment of medroxyprogesterone acetate (MPA) on FM3A breast cancer cells transplanted in female C3H/He mice.
作者信息
Yuyama Yuichi, Yagihashi Atsuhito, Hirata Koichi, Suzuki Yasuyo, Ohmura Tohsei, Okazaki Minoru, Watanabe Naoki
机构信息
Department of Surgery, Sapporo Medical University School of Medicine, Sapporo, South-1, West-16, Sapporo 060-8543, Japan.
出版信息
In Vivo. 2003 May-Jun;17(3):251-4.
BACKGROUND
Little is known about how breast cancer cells are affected by the different regimens of medroxyprogesterone acetate (MPA) hormone therapy in combination with epirubicin (EPI).
MATERIALS AND METHODS
The effectiveness of EPI with and without MPA pretreatment was compared when used on FM3A mouse breast cancer (FM3A) cells transplanted in female C3H/He mice. The effects of these regimens on angiogenesis induced by FM3A tumor were evaluated.
RESULTS
A significant enhancement of the effects of EPI on the growth of FM3A cells by continuous MPA treatment was observed. The continuous treatment of MPA with EPI was most effective in the inhibition of angiogenesis in the tumors in all regimens tested.
CONCLUSION
The combination of MPA pretreatment with EPI may be more effective than the simultaneous treatment of MPA with EPI for breast cancer. In addition, the results suggest that the anti-angiogenic effects of MPA combined with EPI on FM3A cells are parallel with the anti-tumor effects.
背景
关于醋酸甲羟孕酮（MPA）激素疗法与表柔比星（EPI）联合使用的不同方案如何影响乳腺癌细胞，目前所知甚少。
材料与方法
比较了在雌性C3H/He小鼠体内移植的FM3A小鼠乳腺癌（FM3A）细胞上使用有或无MPA预处理的EPI的有效性。评估了这些方案对FM3A肿瘤诱导的血管生成的影响。
结果
观察到通过持续MPA治疗，EPI对FM3A细胞生长的作用显著增强。在所有测试方案中，MPA与EPI的持续联合治疗对肿瘤血管生成的抑制最为有效。
结论
MPA预处理与EPI联合使用可能比MPA与EPI同时治疗乳腺癌更有效。此外，结果表明MPA与EPI联合对FM3A细胞的抗血管生成作用与抗肿瘤作用平行。
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