Haymond M W, Horber F F
Nemour's Children's Clinic, University of Florida Health Science Center, Jacksonville.
Horm Res. 1992;38 Suppl 2:44-6. doi: 10.1159/000182593.
Human growth hormone (GH) increases estimates of whole body protein synthesis, but has little effect on the rates of proteolysis either post-absorptively or when absorption occurs during a meal. In contrast to insulin, GH stimulates protein synthesis in skeletal muscle tissue. Prednisone in high doses induces protein catabolism and has been used as a controlled model for catabolic illness. Prednisone increases the rates of proteolysis and amino acid oxidation, but has little effect on estimates of protein synthesis. The administration of high doses of GH together with prednisone prevents the protein catabolic effects of prednisone alone. Thus, GH may provide a new management strategy in patients with significant protein catabolic conditions.
人生长激素（GH）可提高全身蛋白质合成的估计值，但对吸收后或进餐期间吸收时的蛋白水解速率几乎没有影响。与胰岛素不同，GH可刺激骨骼肌组织中的蛋白质合成。高剂量的泼尼松会诱导蛋白质分解代谢，并已被用作分解代谢性疾病的对照模型。泼尼松可提高蛋白水解速率和氨基酸氧化速率，但对蛋白质合成的估计值影响不大。高剂量的GH与泼尼松联合使用可预防单独使用泼尼松时的蛋白质分解代谢作用。因此，GH可能为患有严重蛋白质分解代谢状况的患者提供一种新的治疗策略。
