Hughes I A, Williams D M, Batch J A, Patterson M N
Department of Paediatrics, University of Cambridge, UK.
Horm Res. 1992;38 Suppl 2:77-81. doi: 10.1159/000182604.
Male pseudohermaphroditism (MPH) is a disorder of sexual differentiation whereby the external genitalia are at variance with a male karyotype and the presence of testes. Abnormalities of Leydig cell function are an important cause of MPH, but postnatal age must be considered when interpreting the testosterone response when HCG stimulation is used as a diagnostic test. Androgen insensitivity is also a common cause of MPH; the specific defect in androgen receptor function is currently the subject of intense study, using a combination of biochemical assays and molecular analysis of the androgen receptor gene. The treatment of MPH is influenced by genital tissue responsiveness to androgens and the technical complexity of reconstructive surgical procedures. There is a need for information on the outcome of MPH treatment regarding pubertal development, sexual performance and fertility.
男性假两性畸形（MPH）是一种性分化障碍，其外生殖器与男性核型及睾丸的存在不一致。莱迪希细胞功能异常是MPH的一个重要原因，但在将人绒毛膜促性腺激素（HCG）刺激用作诊断试验来解释睾酮反应时，必须考虑出生后的年龄。雄激素不敏感也是MPH的常见原因；雄激素受体功能的具体缺陷目前是深入研究的主题，采用了生化分析和雄激素受体基因分子分析相结合的方法。MPH的治疗受生殖器组织对雄激素的反应性以及重建外科手术技术复杂性的影响。需要有关MPH治疗在青春期发育、性功能和生育能力方面结果的信息。
