Sheen Yi-Shuan, Sheen Maw-Chang, Sheu Hamm-Ming, Yang Sheau-Fang, Wang Yi-Wen
Departments of Surgery, Division of Surgical Oncology, Kaohsiung Medical University Hospital, 100 Shih Chuan 1st Road, Kaohsiung, Taiwan.
Dermatol Surg. 2003 Sep;29(9):982-3. doi: 10.1046/j.1524-4725.2003.29267.x.
For preservation of integrity of appearance and function in a 57-year-old male with a squamous cell carcinoma of his left big toe who had refused amputation, intra-arterial infusion with methotrexate was used.
To evaluate the effectiveness of arterial infusion with methotrexate in this uncommon big toe cancer.
Left external iliac arterial catheterization and infusion with methotrexate (50 mg) were used every 24 hours plus simultaneous intramuscular injection of 6 mg of leucovorin every 6 hours for 8 days.
At 7 years and 3 months after therapy, the patient was in sustained complete remission with a functionally normal left foot.
This case study suggests that intra-arterial infusion chemotherapy is a simple and effective method for big toe squamous cell carcinoma with the unique advantage of preservation of organ and function. It can be considered as an effective alternative treatment.
对于一名57岁左大脚趾鳞状细胞癌男性患者，其拒绝截肢，为保持外观和功能完整，采用了甲氨蝶呤动脉内灌注治疗。
评估甲氨蝶呤动脉灌注治疗这种罕见的大脚趾癌症的有效性。
采用左髂外动脉插管，每24小时灌注甲氨蝶呤（50毫克），同时每6小时肌肉注射6毫克亚叶酸钙，共8天。
治疗后7年3个月，患者持续完全缓解，左脚功能正常。
本病例研究表明，动脉内灌注化疗是治疗大脚趾鳞状细胞癌的一种简单有效的方法，具有保留器官和功能的独特优势。可被视为一种有效的替代治疗方法。
