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扩展植入前基因诊断:医学及非医学用途。

Extending preimplantation genetic diagnosis: medical and non-medical uses.

作者信息

Robertson J A

机构信息

Law School, University of Texas, 727 Dean Keeton Street, Austin, Texas, USA.

出版信息

J Med Ethics. 2003 Aug;29(4):213-6. doi: 10.1136/jme.29.4.213.

DOI:10.1136/jme.29.4.213
PMID:12930852
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1733767/
Abstract

New uses of preimplantation genetic diagnosis (PGD) to screen embryos prior to transfer raise ethical, legal, and policy issues that deserve close attention. Extensions for medical purposes, such as to identify susceptibility genes, late onset disease, and human leukocyte antigen (HLA) matching, are usually ethically acceptable. Whether embryo screening for gender, perfect pitch, or other non-medical characteristics are also acceptable depends upon the parental needs served and the harm posed to embryos, children, and society. Speculations about potential future uses of PGD should not prevent otherwise acceptable current uses of PGD.

摘要

胚胎植入前基因诊断(PGD)在胚胎移植前进行筛查的新用途引发了值得密切关注的伦理、法律和政策问题。医学用途的扩展,如识别易感基因、迟发性疾病和人类白细胞抗原(HLA)匹配,通常在伦理上是可以接受的。胚胎性别、绝对音高或其他非医学特征的筛查是否也可接受,取决于所满足的父母需求以及对胚胎、儿童和社会造成的危害。对PGD未来潜在用途的猜测不应妨碍目前其他可接受的PGD用途。

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本文引用的文献

1
Preimplantation diagnosis for p53 tumour suppressor gene mutations.
Reprod Biomed Online. 2001;2(2):102-105. doi: 10.1016/s1472-6483(10)62233-x.
2
Celebrating preimplantation genetic diagnosis of p53 mutations in Li-Fraumeni syndrome.庆祝李-弗劳梅尼综合征中p53突变的植入前基因诊断。
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6
Ethics of preimplantation diagnosis for a woman destined to develop early-onset Alzheimer disease.针对注定会患早发性阿尔茨海默病的女性进行植入前诊断的伦理问题。
JAMA. 2002 Feb 27;287(8):1038-40. doi: 10.1001/jama.287.8.1038.
7
Preimplantation diagnosis for early-onset Alzheimer disease caused by V717L mutation.针对由V717L突变引起的早发性阿尔茨海默病的植入前诊断。
JAMA. 2002 Feb 27;287(8):1018-21. doi: 10.1001/jama.287.8.1018.
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Preconception gender selection.孕前性别选择。
Am J Bioeth. 2001 Winter;1(1):2-9. doi: 10.1162/152651601300048143.
9
Preimplantation sex selection for family balancing in India.
Hum Reprod. 2002 Jan;17(1):11-2. doi: 10.1093/humrep/17.1.11.
10
Preimplantation diagnosis for Fanconi anemia combined with HLA matching.范可尼贫血的植入前诊断及人类白细胞抗原配型
JAMA. 2001 Jun 27;285(24):3130-3. doi: 10.1001/jama.285.24.3130.