Goldsmith-Fischman Sharon, Honig Barry
Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA.
Protein Sci. 2003 Sep;12(9):1813-21. doi: 10.1110/ps.0242903.
The success of structural genomics initiatives requires the development and application of tools for structure analysis, prediction, and annotation. In this paper we review recent developments in these areas; specifically structure alignment, the detection of remote homologs and analogs, homology modeling and the use of structures to predict function. We also discuss various rationales for structural genomics initiatives. These include the structure-based clustering of sequence space and genome-wide function assignment. It is also argued that structural genomics can be integrated into more traditional biological research if specific biological questions are included in target selection strategies.
结构基因组学计划的成功需要开发和应用用于结构分析、预测及注释的工具。在本文中，我们综述了这些领域的最新进展；具体包括结构比对、远源同源物和类似物的检测、同源建模以及利用结构预测功能。我们还讨论了结构基因组学计划的各种基本原理。这些原理包括基于结构的序列空间聚类和全基因组功能分配。我们还认为，如果在目标选择策略中纳入特定的生物学问题，结构基因组学可以融入更传统的生物学研究中。
