Beale K M, Keisling K, Forster-Blouin S
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610-0126.
J Am Vet Med Assoc. 1992 Dec 1;201(11):1715-9.
Fifty-eight dogs with generalized dermatologic disease that had not been given glucocorticoids systemically or topically within 6 weeks of entering the study were evaluated for thyroid function by use of the thyrotropin-response test. Dogs were classified as euthyroid or hypothyroid on the basis of test results and response to thyroid hormone replacement therapy. Baseline serum thyroxine (T4), free T4 (fT4), and triiodothyronine (T3) concentrations were evaluated in the 58 dogs. Serum T4, fT4, and T3 concentrations were evaluated in 200 healthy dogs to establish normal values. Hormone concentrations were considered low if they were less than the mean -2 SD of the values for control dogs. Specificity of T4 and fT4 concentrations was 100% in predicting hypothyroidism; none of the euthyroid dogs with generalized skin disease had baseline serum T4 or fT4 concentration in the low range. Sensitivity was better for fT4 (89%) than for T4 (44%) concentration. Significant difference was not observed in serum T4 and fT4 concentrations between euthyroid dogs with generalized skin disease and healthy control dogs without skin disease. Serum T3 concentration was not accurate in predicting thyroid function; most of the euthyroid and hypothyroid dogs with skin disease had serum T3 concentration within the normal range.
对58只患有全身性皮肤病且在进入研究的6周内未接受过全身性或局部糖皮质激素治疗的犬，通过促甲状腺素反应试验评估其甲状腺功能。根据试验结果及对甲状腺激素替代疗法的反应，将犬分为甲状腺功能正常或甲状腺功能减退。对这58只犬评估了基线血清甲状腺素（T4）、游离T4（fT4）和三碘甲状腺原氨酸（T3）浓度。对200只健康犬评估血清T4、fT4和T3浓度以确定正常值。如果激素浓度低于对照犬值的均值减2个标准差，则认为其浓度较低。T4和fT4浓度预测甲状腺功能减退的特异性为100%；患有全身性皮肤病的甲状腺功能正常犬的基线血清T4或fT4浓度均不在低范围内。fT4浓度的敏感性（89%）高于T4浓度（44%）。患有全身性皮肤病的甲状腺功能正常犬与无皮肤病的健康对照犬之间，血清T4和fT4浓度未观察到显著差异。血清T3浓度在预测甲状腺功能方面不准确；大多数患有皮肤病的甲状腺功能正常和甲状腺功能减退犬的血清T3浓度在正常范围内。
