采用双窗法进行散射校正可使不同γ相机系统中的心脏I-123 MIBG摄取标准化。
Scatter correction by two-window method standardizes cardiac I-123 MIBG uptake in various gamma camera systems.
作者信息
Kobayashi Hideki, Momose Mitsuru, Kanaya Shinichi, Kondo Chisato, Kusakabe Kiyoko, Mitsuhashi Norio
机构信息
Department of Radiology, Tokyo Women's Medical University, Japan.
出版信息
Ann Nucl Med. 2003 Jun;17(4):309-13. doi: 10.1007/BF02988527.
UNLABELLED
Heart to mediastinum count ratio (H/M) has been commonly utilized as an indicator of myocardial I-123 MIBG uptake. However, normal ranges of H/M were markedly different among various gamma camera systems. The purpose of this study was to clarify whether scatter correction by two-window method standardizes H/M among various gamma camera systems.
METHODS
Scatter uncorrected and corrected MIBG imaging was acquired in phantom and human studies in combination with low energy high-resolution collimator (LEHR) and medium energy collimator (MEC). For scatter correction, energy window width of 159 keV +/- 10% was applied to main window imaging and 193 keV +/- 9.5% was applied to upper window imaging for scatter correction.
RESULTS
In phantom study, a significant difference was observed in uncorrected H/M among three gamma camera systems using LEHR or MEC (2.09 +/- 0.06 vs. 2.58 +/- 0.03 in GCA7200 camera, 2.00 +/- 0.07 vs. 2.42 +/- 0.06 in DS7 camera and 2.16 +/- 0.04 vs. 2.67 +/- 0.07 in Vertex plus camera). However, there was no significant difference in corrected H/M among the three gamma camera systems, either with LEHR or MEC (2.70 +/- 0.07 vs. 2.69 +/- 0.07 in GCA7200 camera, 2.66 +/- 0.08 vs. 2.61 +/- 0.05 in DS7 camera and 2.66 +/- 0.05 vs. 2.61 +/- 0.05 in Vertex plus camera). In human study, uncorrected H/M in DS7 camera with LEHC was significantly lower than that in GCA7200 camera with MEC (1.60 +/- 0.37 vs. 1.85 +/- 0.54, N = 14). In contrast, the difference was insignificant in corrected H/M (2.12 +/- 0.59 vs. 2.16 +/- 0.68). There was a very excellent correlation in corrected H/M between DS7 and GCA7200 cameras (r = 0.991, p < 0.001).
CONCLUSION
This study demonstrated that scatter correction by the two-window method standardizes the H/M in MIBG scintigraphy either with LEHR or MEC. Scatter corrected H/M can be applied to measure a standardized parameter of MIBG uptake in human clinical studies using various gamma camera systems.
未标记
心脏与纵隔计数比（H/M）一直被普遍用作心肌I-123 MIBG摄取的指标。然而，不同伽马相机系统之间H/M的正常范围存在显著差异。本研究的目的是阐明双窗法散射校正是否能使不同伽马相机系统的H/M标准化。
方法
在体模和人体研究中，结合低能高分辨率准直器（LEHR）和中能准直器（MEC），采集未校正和校正后的MIBG图像。对于散射校正，主窗成像采用159 keV±10%的能量窗宽，上窗成像采用193 keV±9.5%的能量窗宽进行散射校正。
结果
在体模研究中，使用LEHR或MEC的三种伽马相机系统未校正的H/M存在显著差异（GCA7200相机中为2.09±0.06对2.58±0.03，DS7相机中为2.00±0.07对2.42±0.06，Vertex plus相机中为2.16±0.04对2.67±0.07）。然而，三种伽马相机系统校正后的H/M无论是使用LEHR还是MEC均无显著差异（GCA7200相机中为2.70±0.07对2.69±0.07，DS7相机中为2.66±0.08对2.61±0.05，Vertex plus相机中为2.66±0.05对2.61±0.05）。在人体研究中，使用LEHC的DS7相机未校正的H/M显著低于使用MEC的GCA7200相机（1.60±0.37对1.85±0.54，N = 14）。相比之下，校正后的H/M差异不显著（2.12±0.59对2.16±0.68）。DS7和GCA7200相机校正后的H/M之间存在非常好的相关性（r = 0.991，p < 0.001）。
结论
本研究表明，双窗法散射校正可使使用LEHR或MEC的MIBG闪烁显像中的H/M标准化。散射校正后的H/M可用于在使用各种伽马相机系统的人体临床研究中测量MIBG摄取的标准化参数。
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