Shirota Osamu, Pathak Vibha, Sekita Setsuko, Satake Motoyoshi, Nagashima Yoshio, Hirayama Yutaka, Hakamata Yusuke, Hayashi Tatsuo
Division of Pharmacognosy and Phytochemistry, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.
J Nat Prod. 2003 Aug;66(8):1128-31. doi: 10.1021/np0300683.
Three new phenolic compounds (1-3), along with five known phenolics, 4'-hydroxy-2'-methoxychalcone (4), latinone (5), dalbergiphenol (6), 7-hydroxyflavanone, and dalbergin (7), have been isolated from the stems of Dalbergia cochinchinensis. The structures of 1-3 were established by spectroscopic techniques including 1D and 2D NMR methods. The inhibitory activity against testosterone 5 alpha-reductase, which causes androgen-dependent diseases, was also examined for selected compounds.
从越南黄花梨的茎中分离出了三种新的酚类化合物（1-3），以及五种已知的酚类化合物，4'-羟基-2'-甲氧基查耳酮（4）、拉丁酮（5）、黄檀酚（6）、7-羟基黄烷酮和黄檀素（7）。通过包括一维和二维核磁共振方法在内的光谱技术确定了1-3的结构。还对选定的化合物检测了其对导致雄激素依赖性疾病的睾酮5α-还原酶的抑制活性。
