来自越南黄花梨的酚类成分。

Phenolic constituents from Dalbergia cochinchinensis.

作者信息

Shirota Osamu, Pathak Vibha, Sekita Setsuko, Satake Motoyoshi, Nagashima Yoshio, Hirayama Yutaka, Hakamata Yusuke, Hayashi Tatsuo

机构信息

Division of Pharmacognosy and Phytochemistry, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.

出版信息

J Nat Prod. 2003 Aug;66(8):1128-31. doi: 10.1021/np0300683.

DOI:10.1021/np0300683

PMID:12932142

Abstract

Three new phenolic compounds (1-3), along with five known phenolics, 4'-hydroxy-2'-methoxychalcone (4), latinone (5), dalbergiphenol (6), 7-hydroxyflavanone, and dalbergin (7), have been isolated from the stems of Dalbergia cochinchinensis. The structures of 1-3 were established by spectroscopic techniques including 1D and 2D NMR methods. The inhibitory activity against testosterone 5 alpha-reductase, which causes androgen-dependent diseases, was also examined for selected compounds.

摘要

从越南黄花梨的茎中分离出了三种新的酚类化合物（1-3），以及五种已知的酚类化合物，4'-羟基-2'-甲氧基查耳酮（4）、拉丁酮（5）、黄檀酚（6）、7-羟基黄烷酮和黄檀素（7）。通过包括一维和二维核磁共振方法在内的光谱技术确定了1-3的结构。还对选定的化合物检测了其对导致雄激素依赖性疾病的睾酮5α-还原酶的抑制活性。