大鼠心脏中动脉的生理生长与毛细血管的生长平行，但与心肌细胞的生长不平行。

Physiological growth of arteries in the rat heart parallels the growth of capillaries, but not of myocytes.

作者信息

Wiest G, Gharehbaghi H, Amann K, Simon T, Mattfeldt T, Mall G

机构信息

Department of Pathology, University of Heidelberg, Germany.

出版信息

J Mol Cell Cardiol. 1992 Dec;24(12):1423-31. doi: 10.1016/0022-2828(92)91083-h.

DOI:10.1016/0022-2828(92)91083-h

PMID:1293316

Abstract

Maladaption to hemodynamic overload, especially to arterial hypertension, has important clinical implications, and it is necessary to obtain criteria in order to discriminate physiological and pathological growth processes. We investigated the physiological growth of intramyocardial arteries in the rat heart. A new stereological method was introduced to determine the length of intramyocardial arteries from counts on histological sections. Four groups of male Sprague-Dawley rats of different ages were investigated. The growth rate of arteries was characterized by the growth coefficient b according to the exponential function y = axb (allometric growth function). Analysis of left ventricular weights (LVW) and total lengths of left ventricular intramyocardial arteries (L) revealed Lv = constant.LVW0.71 (r = 0.77, P < 0.001). The growth coefficient b < 1 indicates that the arterial supply of the heart, i.e. the length density of arteries Lv (length per unit myocardial volume), decreases during normal growth. Empirically, we found L = constant.LVW-0.28 (r = 0.43, P < 0.01). Previously, we estimated growth rates of b = 0.33 for the total length of left ventricular myocytes and b = 0.71 for the total length of capillaries. Thus, growth of intramyocardial arteries considerably exceeds the length increase of myocytes, but is proportional to the length increase of capillaries. Growth analysis of total mitochondrial volume using historical data of our group revealed proportionality to arteries, as well (b = 0.76). This indicates that growth of arteries and capillaries may be determined by oxygen consumption.

摘要

对血流动力学过载尤其是动脉高血压的适应不良具有重要的临床意义，因此有必要获取标准以区分生理和病理生长过程。我们研究了大鼠心脏心肌内动脉的生理性生长。引入了一种新的体视学方法，通过对组织学切片的计数来确定心肌内动脉的长度。研究了四组不同年龄的雄性斯普拉格 - 道利大鼠。根据指数函数y = ax^b（异速生长函数），动脉的生长速率由生长系数b表征。对左心室重量（LVW）和左心室心肌内动脉总长度（L）的分析显示L =常数·LVW^0.71（r = 0.77，P < 0.001）。生长系数b < 1表明心脏的动脉供应，即动脉长度密度Lv（每单位心肌体积的长度）在正常生长过程中会降低。根据经验，我们发现L =常数·LVW^ - 0.28（r = 0.43，P < 0.01）。此前，我们估计左心室心肌细胞总长度的生长速率b = 0.33，毛细血管总长度的生长速率b = 0.71。因此，心肌内动脉的生长显著超过心肌细胞长度的增加，但与毛细血管长度的增加成比例。利用我们小组的历史数据对线粒体总体积进行生长分析，结果也显示与动脉成比例（b = 0.76）。这表明动脉和毛细血管的生长可能由氧消耗决定。