基因变异会影响B细胞对肺炎球菌多糖结合疫苗免疫接种的反应。
Genetic variation influences the B-cell response to immunization with a pneumococcal polysaccharide conjugate vaccine.
作者信息
McCool T L, Schreiber J R, Greenspan N S
机构信息
Department of Pathology, Case Western Reserve University, Cleveland Ohio 44106, USA.
出版信息
Infect Immun. 2003 Sep;71(9):5402-6. doi: 10.1128/IAI.71.9.5402-5406.2003.
Abstract
CBA/J mice immunized with pneumococcal 23F-CRM(197) vaccine produce significantly lower titers of 23F-specific antibodies and fewer 23F-specific antibody-secreting cells (ASC) than did BALB/c or (CBA/J x BALB/c)F(1) (CCBAF(1)) mice. The reduced 23F-specific titers of CBA/J versus BALB/c or CCBAF(1) mice are presumably related to lower frequencies of 23F-specific ASC influenced by genetic variation.
摘要
用肺炎球菌23F-CRM（197）疫苗免疫的CBA/J小鼠产生的23F特异性抗体滴度明显低于BALB/c或（CBA/J×BALB/c）F1（CCBAF1）小鼠，且23F特异性抗体分泌细胞（ASC）数量也更少。与BALB/c或CCBAF1小鼠相比，CBA/J小鼠23F特异性滴度降低可能与受遗传变异影响的23F特异性ASC频率较低有关。
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