Herrero Mónica, Rodríguez Adelaida, Cejas Hugo
3a Cátedra de Patología-Facultad de Ciencias Médicas-Hospital Misericordia Universidad Nacional de Córdoba.
Rev Fac Cien Med Univ Nac Cordoba. 2002;59(1):91-6.
From the first description of Pretl in 1944, many authors have shown different morphological and immunohistochemical studies related to prostatic neuroendocrine cells. These cells belong to a neuroendocrine system, wide disseminated network, that is found in many human tissues. They secret neuroendocrine peptides and play an important role in the glandular epithelium regulation (growing, differentiation, and exocrine secretion), in both normal and hyperplastic glands. They are also present in ordinary prostatic adenocarcinoma and in unusual small cell carcinoma. Recently, it has been suggested that prostatic neuroendocrine cells may be related to prognosis in prostatic carcinoma, particularly in cases with hormonal therapy resistant. In this study, there are 23 prostatic disorders: 11 nodular hyperplasias and 12 adenocarcinomas, and also areas of normal gland. The objective is the morphologic identification of these cells with silver impregnation technique, in normal tissue, nodular hyperplasia and adenocarcinoma. In normal gland and nodular hyperplasia, the NE cells can be seen along most of the gland or near the urethra, solitary or in small clusters. These cells are located between acinar epithelium cells and basement membrane, but they are also found within the stroma in relation to nerve endings. They characteristically contain argyrophil and argentaffin granules in the cytoplasm and exhibit cytoplasmatic processes extended to acinar or urethral lumen. Within the stroma, they are seen isolated with dendritic or ribbon-like cytoplasmatic processes. In this study, there is only one adenocarcinoma of high grade with NE cells. In this neoplasm they are increase in number, and appear isolated and more polymorphic.
自1944年普雷特尔首次描述以来，许多作者展示了与前列腺神经内分泌细胞相关的不同形态学和免疫组织化学研究。这些细胞属于一个神经内分泌系统，这是一个广泛分布的网络，存在于许多人体组织中。它们分泌神经内分泌肽，在正常和增生性腺体的腺上皮调节（生长、分化和外分泌）中发挥重要作用。它们也存在于普通前列腺腺癌和不常见的小细胞癌中。最近，有人提出前列腺神经内分泌细胞可能与前列腺癌的预后有关，特别是在对激素治疗耐药的病例中。在这项研究中，有23例前列腺疾病：11例结节性增生和12例腺癌，还有正常腺体区域。目的是用银浸染技术在正常组织、结节性增生和腺癌中对这些细胞进行形态学鉴定。在正常腺体和结节性增生中，神经内分泌细胞可见于大部分腺体或尿道附近，单个或成小簇。这些细胞位于腺泡上皮细胞和基底膜之间，但也见于与神经末梢相关的基质内。它们的细胞质中典型地含有嗜银和亲银颗粒，并表现出延伸至腺泡或尿道腔的细胞质突起。在基质内，它们以具有树突状或带状细胞质突起的形式孤立存在。在这项研究中，只有一例高级别腺癌伴有神经内分泌细胞。在这种肿瘤中，它们的数量增加，且呈孤立状且形态更多样化。
