Urbani G, Filippini P, Lombardo G, Consolo U, Cuzzolin L, Benoni G
Istituto di Clinica Odontoiatrica, Università degli Studi di Verona.
Minerva Stomatol. 1992 Oct;41(10):435-43.
The periodontal pack is often used to cover the surgical site after surgery, even when associated with local applications of preparations containing chlorexidine, in order to obtain an antiseptic protection. However many people question whether the drug effectively succeeds in penetrating the pack, or if the presence of the pack itself doesn't obstruct the action of the medication. The aim of this work is to evaluate the efficiency of the clorexidine in the surgical area with and without a periodontal pack. In a first stage, a case was chosen and contemporary operated on in two different but anatomically similar sites at the same time. One of the two sites was covered with a chlorexidine gel for the following week, whilst the other was left without medication. After seven days the stitches removed from the two different sites were placed in culture mediums to number and classify the bacterial strains present. In the second stage of the experiment, another eight patients were operated on in the same way, and the two sites covered with periodontal packs. In one of the two sites a layer of chlorexidine gel was positioned under the pack, and the chlorexidine above and on the sides of the pack was continually renewed throughout the week following the operation. The other site was not treated. The results obtained show that the pack partially reduces the action of the drug medication, probably because an insufficient amount reaches the site. The activity and efficiency of chlorexidine against the strains of bacteria found in vivo were tested in vitro. The chlorexidine destroyed all of them.(ABSTRACT TRUNCATED AT 250 WORDS)
牙周塞治剂常用于术后覆盖手术部位，即使在联合应用含氯己定的制剂时也是如此，目的是获得抗菌保护。然而，许多人质疑药物是否能有效穿透塞治剂，或者塞治剂本身的存在是否会阻碍药物的作用。这项工作的目的是评估有和没有牙周塞治剂时氯己定在手术区域的效果。在第一阶段，选择一个病例，同时在两个不同但解剖结构相似的部位进行手术。两个部位中的一个在接下来的一周用氯己定凝胶覆盖，而另一个不使用药物。七天后，从两个不同部位取出的缝线被置于培养基中，对存在的细菌菌株进行计数和分类。在实验的第二阶段，另外八名患者以同样的方式进行手术，两个部位用牙周塞治剂覆盖。在两个部位中的一个，在塞治剂下方放置一层氯己定凝胶，并且在手术后的一周内持续更新塞治剂上方和侧面的氯己定。另一个部位不进行治疗。获得的结果表明，塞治剂会部分降低药物的作用，可能是因为到达该部位的药量不足。在体外测试了氯己定对体内发现的细菌菌株的活性和效果。氯己定将所有这些细菌都消灭了。（摘要截短至250字）
