Panattoni G L, Corvetti G, Sisto Daneo L
Department of Human Anatomy and Physiology, University of Turin, Italy.
Panminerva Med. 1992 Oct-Dec;34(4):155-9.
The authors focused their attention on the cytology of the degenerating notochord at the level of the vertebral anlagen and compared it with data of the literature on the histopathology of the spinal chordomas. The purpose of the research was to investigate the notochordal histological features justifying the fact that the remnants of a structure destined to atrophy during prenatal life, maintain a proliferative potential in postnatal life. Therefore, from the earliest stages (24th incubation hour) to the terms of development, the notochord was studied by electron microscope in chick embryo. The data obtained show that, in most notochordal cells, signs of metabolic damage and progressive degeneration coexist with signs of secretory and mitotic activity, from which the proliferative potential of these cells seems to derive. Vacuolar degeneration is also likely due to the progressive metabolic segregation of the notochord, owing to the absence of blood-vessels and the appearance of perichordal sheath.
作者将注意力集中在椎体原基水平处退化脊索的细胞学上，并将其与关于脊索瘤组织病理学的文献数据进行比较。该研究的目的是调查脊索的组织学特征，以解释这样一个事实：一个在产前生命中注定会萎缩的结构的残余部分，在产后生命中仍保持增殖潜力。因此，从最早阶段（孵化后第24小时）到发育阶段，通过电子显微镜对鸡胚中的脊索进行了研究。获得的数据表明，在大多数脊索细胞中，代谢损伤和渐进性退化的迹象与分泌和有丝分裂活动的迹象并存，这些细胞的增殖潜力似乎由此而来。空泡变性也可能是由于脊索缺乏血管和脊索周鞘的出现导致的渐进性代谢分离所致。
