Kang Jong Soon, Park Song-Kyu, Yang Kyu-Hwan, Kim Hwan Mook
Biopotency Evaluation Laboratory, Korea Research Institute of Bioscience and Biotechnology, Taejon 305-333, South Korea.
FEBS Lett. 2003 Aug 28;550(1-3):89-93. doi: 10.1016/s0014-5793(03)00827-5.
Silymarin is known to have an anti-atherosclerotic activity, but the mechanism responsible for it remains unclear. Here, we demonstrate a possible mechanism involved in the anti-atherosclerotic activity of silymarin. Silymarin inhibited THP-1 cell adhesion to human umbilical vein endothelial cells (HUVECs). Silymarin also suppressed the TNF-alpha-induced protein and mRNA expression of adhesion molecules, such as VCAM-1, ICAM-1 and E-selectin, in HUVECs. Moreover, silymarin suppressed the TNF-alpha-induced DNA binding of NF-kappaB/Rel in HUVECs. Taken together, these results demonstrate that silymarin exerts an anti-atherosclerotic activity, at least in part, by inhibiting the expression of adhesion molecules.
水飞蓟素具有抗动脉粥样硬化活性，但其作用机制尚不清楚。在此，我们展示了水飞蓟素抗动脉粥样硬化活性可能涉及的机制。水飞蓟素抑制THP-1细胞与人脐静脉内皮细胞（HUVECs）的黏附。水飞蓟素还抑制肿瘤坏死因子-α（TNF-α）诱导的HUVECs中黏附分子如血管细胞黏附分子-1（VCAM-1）、细胞间黏附分子-1（ICAM-1）和E-选择素的蛋白和mRNA表达。此外，水飞蓟素抑制TNF-α诱导的HUVECs中NF-κB/Rel的DNA结合。综上所述，这些结果表明水飞蓟素至少部分通过抑制黏附分子的表达发挥抗动脉粥样硬化活性。
