新生儿血小板减少症：病因与管理
Neonatal thrombocytopenia: causes and management.
作者信息
Roberts I, Murray N A
机构信息
Imperial College, Hammersmith Campus, London W12 0NN, UK.
出版信息
Arch Dis Child Fetal Neonatal Ed. 2003 Sep;88(5):F359-64. doi: 10.1136/fn.88.5.f359.
Abstract
Neonatal thrombocytopenia is a common clinical problem. Thrombocytopenia presenting in the first 72 hours of life is usually secondary to placental insufficiency and caused by reduced platelet production; fortunately most episodes are mild or moderate and resolve spontaneously. Thrombocytopenia presenting after 72 hours of age is usually secondary to sepsis or necrotising enterocolitis and is usually more severe and prolonged. Platelet transfusion remains the only treatment. There is a need for trials to define the safe lower limit for platelet count and which neonates will benefit from treatment.
摘要
新生儿血小板减少症是一个常见的临床问题。出生后72小时内出现的血小板减少症通常继发于胎盘功能不全，由血小板生成减少引起；幸运的是，大多数病例为轻度或中度，可自行缓解。出生72小时后出现的血小板减少症通常继发于败血症或坏死性小肠结肠炎，通常更严重且持续时间更长。血小板输注仍然是唯一的治疗方法。需要进行试验来确定血小板计数的安全下限以及哪些新生儿将从治疗中受益。
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