Olsson Bob, Andersson Per-Ola, Jernås Margareta, Jacobsson Stefan, Carlsson Björn, Carlsson Lena M S, Wadenvik Hans
Research Center for Endocrinology and Metabolism, Sahlgrenska University Hospital, Göteborg University, SE-413 45 Göteborg, Sweden.
Nat Med. 2003 Sep;9(9):1123-4. doi: 10.1038/nm921. Epub 2003 Aug 24.
Chronic idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder that is characterized by increased platelet destruction and is believed to be autoantibody mediated. In this study, CD3+ T cells from ITP patients had increased expression of genes involved in cell-mediated cytotoxicity. In addition, cytotoxic cell-mediated lysis of autologous platelets was shown in active ITP. Our data suggest that T-cell-mediated cytotoxicity is an alternative mechanism for platelet destruction in ITP.
慢性特发性血小板减少性紫癜（ITP）是一种出血性疾病，其特征是血小板破坏增加，被认为是由自身抗体介导的。在本研究中，ITP患者的CD3 + T细胞中参与细胞介导的细胞毒性的基因表达增加。此外，在活动性ITP中显示出细胞毒性细胞介导的自体血小板裂解。我们的数据表明，T细胞介导的细胞毒性是ITP中血小板破坏的另一种机制。
