Tomita N, Morishita R, Kaneda Y, Higaki J, Ogihara T
Department of General Medicine, Osaka University Hospital, Suita, Japan.
Drug News Perspect. 2000 May;13(4):206-12.
Cardiovascular disease is the leading cause of mortality and morbidity in developed countries. Most conventional therapy is inefficient and tends to treat the symptoms rather than the underlying causes of the disorder. Gene therapy offers a novel approach for the prevention and treatment of cardiovascular diseases. Gene transfer into somatic cells to interfere with the pathogenetic processes contributing to cardiovascular disease may provide such a novel approach for better prevention and treatment of cardiovascular disorders. The major development of gene transfer has importantly contributed to intense investigation of the potential of gene therapy in cardiovascular medicine. The amazing advances in molecular biology have provided a dramatic improvement in the technology that is necessary to transfer target genes into somatic cells. Recently, transfection of cis element double-stranded oligonucleotides (ODN), referred to as decoy ODN, has been reported to be a powerful tool in a new class of antigene strategies for gene therapy. In this article, we review the successful treatment of restenosis and myocardial infarction using the decoy strategy combined with an efficient gene transfer method.
心血管疾病是发达国家死亡和发病的主要原因。大多数传统疗法效率低下，往往只能治疗症状而非疾病的根本原因。基因治疗为心血管疾病的预防和治疗提供了一种新方法。将基因导入体细胞以干扰导致心血管疾病的致病过程，可能为更好地预防和治疗心血管疾病提供这样一种新方法。基因转移的重大进展对基因治疗在心血管医学中的潜力进行深入研究起到了重要作用。分子生物学的惊人进展极大地改进了将靶基因导入体细胞所需的技术。最近，顺式元件双链寡核苷酸（ODN）的转染，即所谓的诱饵ODN，已被报道是一类新型基因治疗反基因策略中的有力工具。在本文中，我们综述了诱饵策略与高效基因转移方法相结合成功治疗再狭窄和心肌梗死的情况。
