Luo H, Zhao G, He R R
Department of Physiology, Institute of Basic Medicine, Hebei Medical College, Shijiazhuang.
Sheng Li Xue Bao. 1992 Oct;44(5):515-9.
Application of atrial natriuretic peptides (alpha-ANP and AP III) to glutamate sensitive area of ventrolateral medulla produced a dose-dependent decrease in MAP and HR in anesthetized rats. Lower dosage of AP III induced hypotension without bradycardia, whereas the higher dosage of AP III decreased both blood pressure and heart rate. The results suggested that ANP may inhibit the medullary sympathetic center.
