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[Masked Philadelphia chromosome: diagnostic implications in a case of chronic myeloid leukemia presenting in blast crisis].

作者信息

Carrasco J L, Hernández García M T, Otero A, Vilar M C, Marsá L, González Brito G, García Miranda J L, Hernández Nieto L

机构信息

Servicio de Citogenética, Facultad de Medicina, Universidad de la Laguna, Tenerife, Islas Canarias, España.

出版信息

Sangre (Barc). 1992 Oct;37(5):395-8.

PMID:1293781
Abstract

We present a female patient with acute non-lymphoblastic leukemia (ANLL) and with haematologic features suggestive of its evolution from chronic myeloid leukaemia (CML), in which a bone marrow karyotype showing a "masked" Philadelphia (Ph) chromosome due to a variant translocation of complex type t(9;9;22)(q32;q34;q11) was found. We comment the peculiarities of this special Ph chromosome as well as the differential diagnostic problems between ANLL Ph(+) and CML with onset in blastic crisis.

摘要

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