McCracken Ardythe A, Brodsky Jeffrey L
Biology Department, University of Nevada, Reno, Nevada 89557, USA.
Bioessays. 2003 Sep;25(9):868-77. doi: 10.1002/bies.10320.
ER-associated degradation (ERAD) is a component of the protein quality control system, ensuring that aberrant polypeptides cannot transit through the secretory pathway. This is accomplished by a complex sequence of events in which unwanted proteins are selected in the ER and exported to the cytosol for degradation by the proteasome. Given that protein quality control can be essential for cell survival, it is not surprising that ERAD is linked to numerous disease states. Here we review the molecular mechanisms of ERAD, its role in metabolic regulation and biomedical implications, and the unanswered questions regarding this process.
内质网相关降解（ERAD）是蛋白质质量控制系统的一个组成部分，可确保异常多肽无法通过分泌途径转运。这是通过一系列复杂的事件来实现的，在这些事件中，内质网中不需要的蛋白质被挑选出来并输出到细胞质中，由蛋白酶体进行降解。鉴于蛋白质质量控制对细胞存活至关重要，ERAD与众多疾病状态相关也就不足为奇了。在这里，我们综述了ERAD的分子机制、其在代谢调节中的作用和生物医学意义，以及关于这一过程尚未解决的问题。
