蛋白质从内质网逆向转运至细胞质溶胶。

Retro-translocation of proteins from the endoplasmic reticulum into the cytosol.

作者信息

Tsai Billy, Ye Yihong, Rapoport Tom A

机构信息

Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Nat Rev Mol Cell Biol. 2002 Apr;3(4):246-55. doi: 10.1038/nrm780.

DOI:10.1038/nrm780

PMID:11994744

Abstract

Proteins that are misfolded in the endoplasmic reticulum are transported back into the cytosol for destruction by the proteasome. This retro-translocation pathway has been co-opted by certain viruses, and by plant and bacterial toxins. The mechanism of retro-translocation is still mysterious, but several aspects of this process are now being unravelled.

摘要

在内质网中错误折叠的蛋白质会被转运回细胞质，由蛋白酶体进行降解。某些病毒、植物毒素和细菌毒素利用了这种逆向转运途径。逆向转运的机制仍然神秘，但这一过程的几个方面现在正在被揭示。