[磺化邻苯二甲酰亚胺甲基锌酞菁在CEL溶液中的聚集态研究]

[Study on the aggregation state of sulfonated phthalimidomethyl zinc phthalocyanine in CEL solution].

作者信息

Peng Y, Xue J, Huang J, Lin Z, Liu E, Chen N, Huang J

机构信息

Department of Chemistry, Institute of Functional Material, Fuzhou University, 350002 Fuzhou.

出版信息

Guang Pu Xue Yu Guang Pu Fen Xi. 2000 Dec;20(6):875-7.

PMID:12938501

Abstract

Sulfonated Phthalimidomethyl Zinc Phthalocyanine is a new photodynamic therapy reagent, it can be selectively attacked to cell, but how it attacks the target cell is still unknowable. The aggregation state of photosensitizer is significant to its mechanism proved in CEL solution. The aggregation of ZnPcS2P2 in CEL has been studied with absorption spectroscopy and fluorescence spectroscopy. The aggregation state is dimer through theory analysis, monomer molar absorption coefficient as well as equilibrium constant were estimated.

摘要

磺化邻苯二甲酰亚胺甲基锌酞菁是一种新型光动力治疗试剂，它能选择性地作用于细胞，但其如何作用于靶细胞仍不清楚。在CEL溶液中已证明光敏剂的聚集状态对其作用机制至关重要。已用吸收光谱和荧光光谱研究了CEL中ZnPcS2P2的聚集情况。通过理论分析可知其聚集状态为二聚体，并估算了单体摩尔吸收系数和平衡常数。