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醋酸格拉替雷(考帕松)对多发性硬化症发病机制不同阶段的影响

[Glatiramer acetate (Copaxone) influence on different stages of multiple sclerosis pathogenesis].

作者信息

Shmidt T E, Zhuchenko T D, Iakhno N N

出版信息

Zh Nevrol Psikhiatr Im S S Korsakova. 2003(Spec No 2):79-82.

Abstract

Multiple sclerosis (MS)--autoimmune disease of CNS, characterized by myelin destruction and axonal damage. The action of drugs recommended for its treatment [symbol: see text] aimy[symbol: see text] at the reduction of the autoimmune responses. These responses lead to the neurological damage. One of immunoregulators is glatiramer acetate--Copaxone. Copaxone acts at different phases of MS pathogenesis and probably has a neuroprotective action. Copaxone reduces the rate of relapses and leads to clinical stabilisation in cases of relapsing-remmiting MS. Its efficacy and safety has been confirmed in long-term clinical and MRI-trials. Copaxone has few side-effects that are non-significant.

摘要

多发性硬化症(MS)——中枢神经系统的自身免疫性疾病,其特征为髓鞘破坏和轴突损伤。推荐用于其治疗的药物的作用[符号:见原文]旨在[符号:见原文]降低自身免疫反应。这些反应会导致神经损伤。免疫调节剂之一是醋酸格拉替雷——考帕松。考帕松作用于MS发病机制的不同阶段,可能具有神经保护作用。考帕松可降低复发率,并使复发缓解型MS患者实现临床稳定。其疗效和安全性已在长期临床和MRI试验中得到证实。考帕松的副作用很少且不显著。

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Glatiramer acetate for the treatment of multiple sclerosis.醋酸格拉替雷用于治疗多发性硬化症。
Expert Opin Pharmacother. 2004 Apr;5(4):875-91. doi: 10.1517/14656566.5.4.875.

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