Holbrook John M, Cohen Paul G
Department of Pharmaceutical Sciences, Southern School of Pharmacy, Mercer University, Atlanta, GA 30341, USA.
South Med J. 2003 Jun;96(6):544-7. doi: 10.1097/01.SMJ.0000056702.78679.71.
Idiopathic hypogonadotropic hypogonadism (IHH) has been observed to occur in men with premature ejaculation (PE). Common IHH therapies include testosterone replacement, which increases testosterone levels but suppresses gonadotropin release; and gonadotropin-releasing hormone supplementation, which restores gonadotropin levels but is impractical for chronic use. Hormonal imbalances associated with IHH/PE are thought to be related to hyperactivity of the cytochrome P-450 enzyme aromatase.
Ten male patients with a diagnosis of IHH/PE were treated with the aromatase inhibitor anastrazole (1 mg/d orally). Levels of free and total testosterone, luteinizing hormone, follicle-stimulating hormone, prolactin, and estradiol were determined at baseline and after 2 weeks of therapy.
After 2 weeks of therapy with anastrazole, levels of testosterone, luteinizing hormone, and estradiol had returned to normal. No effect was noted on premature ejaculation.
These results suggest that aromatase inhibition with anastrazole may provide a practical and efficacious alternative for the treatment of IHH but is not effective in preventing premature ejaculation.
特发性低促性腺激素性性腺功能减退（IHH）在早泄（PE）男性中已有观察报道。常见的IHH治疗方法包括睾酮替代疗法，其可提高睾酮水平但会抑制促性腺激素释放；以及促性腺激素释放激素补充疗法，其可恢复促性腺激素水平但不适合长期使用。与IHH/PE相关的激素失衡被认为与细胞色素P - 450酶芳香化酶的活性过高有关。
对10例诊断为IHH/PE的男性患者使用芳香化酶抑制剂阿那曲唑（口服1毫克/天）进行治疗。在基线及治疗2周后测定游离睾酮、总睾酮、黄体生成素、卵泡刺激素、催乳素和雌二醇的水平。
使用阿那曲唑治疗2周后，睾酮、黄体生成素和雌二醇水平恢复正常。未观察到对早泄有任何影响。
这些结果表明，阿那曲唑抑制芳香化酶可能为治疗IHH提供一种实用且有效的替代方法，但对预防早泄无效。
