肺曲霉病和中枢神经系统出血作为接受皮质类固醇治疗的自身免疫性溶血性贫血的并发症。
Pulmonary aspergillosis and central nervous system hemorrhage as complications of autoimmune hemolytic anemia treated with corticosteroids.
作者信息
Cleri Dennis J, Moser Robert L, Villota Francisco J, Wang Yue, Husain Syed A, Nadeem Shahzinah, Anjari Tarek, Sajed Mohammad
机构信息
Department of Medicine, St. Francis Medical Center, Seton Hall University School of Graduate Medical Education, Trenton, NJ 08629-1986, USA.
出版信息
South Med J. 2003 Jun;96(6):592-5. doi: 10.1097/01.SMJ.0000056645.47125.96.
Warm, active antibody adult autoimmune hemolytic anemia is the most common form of hemolytic anemia not related to drug therapy. Mortality in adult autoimmune hemolytic anemia is related to the inability to successfully treat patients' underlying disease, or the infectious complications of splenectomy and prolonged steroid therapy. Predisposing factors for invasive aspergillosis are neutropenia and steroid therapy. We present a fatal case of aspergillosis complicating a nonneutropenic case of warm active antibody adult autoimmune hemolytic anemia treated with prolonged steroid therapy.
温抗体型成人自身免疫性溶血性贫血是最常见的与药物治疗无关的溶血性贫血形式。成人自身免疫性溶血性贫血的死亡率与无法成功治疗患者的基础疾病、脾切除术后的感染并发症以及长期使用类固醇治疗有关。侵袭性曲霉病的易感因素是中性粒细胞减少和类固醇治疗。我们报告了一例曲霉病致死病例，该病例使一名非中性粒细胞减少的温抗体型成人自身免疫性溶血性贫血患者在接受长期类固醇治疗后病情复杂化。
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