Tabajara Angela Sampaio, Fontella Fernanda Urruth, Torres Iraci Lucena da Silva, Dalmaz Carla
Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, UFRGS. Porto Alegre, Brazil.
Neurochem Res. 2003 Sep;28(9):1315-20. doi: 10.1023/a:1024932028999.
Behavioral and neurochemical gender-specific effects have been observed following repeated stress. The aim of this study is to verify the effects of repeated restraint stress on free radical production (evaluated by DCF test), lipoperoxidation (evaluated by TBARS levels), and total antioxidant reactivity (TAR) in the spinal cord of male and female rats. Results demonstrate no effect on lipoperoxidation; chronic stress decreased TAR both in male and female spinal cord. In addition, gender differences were observed both in TAR and in the production of free radicals, both being increased in females. These results may be relevant to the gender-specific differences observed after exposure to repeated stress.
反复应激后已观察到行为和神经化学方面的性别特异性效应。本研究的目的是验证反复束缚应激对雄性和雌性大鼠脊髓中自由基产生（通过DCF试验评估）、脂质过氧化（通过TBARS水平评估）和总抗氧化反应性（TAR）的影响。结果表明对脂质过氧化无影响；慢性应激降低了雄性和雌性脊髓中的TAR。此外，在TAR和自由基产生方面均观察到性别差异，两者在雌性中均增加。这些结果可能与反复应激后观察到的性别特异性差异有关。
