Zajworoniuk H, Rzeczycki W
Department of General Chemistry, Medical Academy, Gdańsk, Poland.
Acta Biochim Pol. 1992;39(4):335-43.
Increased catalase activity was observed in the liver microsomal fraction of ethanol-treated rats (10% v/v aqueous ethanol solution per os for 5 weeks). In contrast, cytochrome P-450 concentration and specific activity of NADPH-cytochrome c reductase remained at the same level as in the liver of control rats (drinking water). The ratio of microsomal H2O2-generation to catalase activity was lower in the "ethanol" group than in the control one. This phenomenon seems to be related to the increased contribution of the "peroxidatic" reaction (increased rate of ethanol oxidation). Administration of mesitylene (1,3,5-trimethylbenzene) by gastric tube for 3 days (5 mmoles per kg daily) increased cytochrome P-450 concentration, specific activity of NADPH-cytochrome c reductase and ethanol metabolism.
在经乙醇处理的大鼠肝脏微粒体部分中观察到过氧化氢酶活性增加（经口给予10% v/v乙醇水溶液，持续5周）。相比之下，细胞色素P-450浓度和NADPH-细胞色素c还原酶的比活性与对照大鼠（饮用自来水）肝脏中的水平保持相同。“乙醇”组微粒体H2O2生成与过氧化氢酶活性的比率低于对照组。这种现象似乎与“过氧化物酶”反应的贡献增加（乙醇氧化速率增加）有关。通过胃管给予均三甲苯（1,3,5-三甲基苯）3天（每天5毫摩尔/千克）可增加细胞色素P-450浓度、NADPH-细胞色素c还原酶的比活性以及乙醇代谢。
