Fisson Sylvain, Darrasse-Jèze Guillaume, Litvinova Elena, Septier Franck, Klatzmann David, Liblau Roland, Salomon Benoît L
CNRS UMR 7087, Batiment CERVI, Hôpital de la Pitié-Salpêtrière, 83 Boulevard de l'Hôpital, 75013 Paris, France.
J Exp Med. 2003 Sep 1;198(5):737-46. doi: 10.1084/jem.20030686. Epub 2003 Aug 25.
Despite a growing interest in CD4+ CD25+ regulatory T cells (Treg) that play a major role in self-tolerance and immunoregulation, fundamental parameters of the biology and homeostasis of these cells are poorly known. Here, we show that this population is composed of two Treg subsets that have distinct phenotypes and homeostasis in normal unmanipulated mice. In the steady state, some Treg remain quiescent and have a long lifespan, in the order of months, whereas the other Treg are dividing extensively and express multiple activation markers. After adoptive transfer, tissue-specific Treg rapidly divide and expand preferentially in lymph nodes draining their target self-antigens. These results reveal the existence of a cycling Treg subset composed of autoreactive Treg that are continuously activated by tissue self-antigens.
尽管人们对在自身耐受和免疫调节中起主要作用的CD4+ CD25+调节性T细胞（Treg）的兴趣日益浓厚，但这些细胞生物学和稳态的基本参数却鲜为人知。在这里，我们表明，在正常未处理的小鼠中，这一群体由两个具有不同表型和稳态的Treg亚群组成。在稳态下，一些Treg保持静止，寿命长达数月，而另一些Treg则大量增殖并表达多种激活标志物。过继转移后，组织特异性Treg在引流其靶自身抗原的淋巴结中迅速增殖并优先扩增。这些结果揭示了一个由自身反应性Treg组成的循环Treg亚群的存在，这些自身反应性Treg被组织自身抗原持续激活。
