晚期帕金森病患者脑脊液中食欲素/下丘脑泌素水平较低。
Low levels of ventricular CSF orexin/hypocretin in advanced PD.
作者信息
Drouot X, Moutereau S, Nguyen J P, Lefaucheur J P, Créange A, Remy P, Goldenberg F, d'Ortho M P
机构信息
Service de Physiologie-Explorations Fonctionnelles, Unité Inserm U421-Université Paris XII, Faculté de Médecine de Créteil, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil, France.
出版信息
Neurology. 2003 Aug 26;61(4):540-3. doi: 10.1212/01.wnl.0000078194.53210.48.
The origins of excessive daytime sleepiness in Parkinson disease (PD) are unclear. The authors hypothesize that orexin neurons, a recently identified wake promoting system, could contribute to its pathophysiology. They measured orexin-A/hypocretin-1 concentration in ventricular CSF in 19 parkinsonian patients and compared it with neurologic controls. Orexin levels were lower in patients and decreased with the severity of the disease. The authors suggest that orexin neurons contribute to daytime sleepiness in late stage PD.
帕金森病（PD）患者日间过度嗜睡的病因尚不清楚。作者推测，食欲素神经元是最近发现的一种促进觉醒的系统，可能在其病理生理过程中起作用。他们测量了19例帕金森病患者脑室脑脊液中食欲素-A/下丘脑泌素-1的浓度，并与神经科对照者进行了比较。患者的食欲素水平较低，且随疾病严重程度而降低。作者认为，食欲素神经元在晚期帕金森病患者日间嗜睡中起作用。
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