Rauch U, Schäfer K-H
Department of Paediatric Surgery, Clinical Hospital Mannheim, University Heidelberg, Theodor-Kutzer-Ufer 1-3, 68135 Mannheim, Germany.
Eur J Pediatr Surg. 2003 Jun;13(3):158-62. doi: 10.1055/s-2003-41265.
The extracellular matrix (ECM), a network consisting of many different macromolecules, fulfils many important functions in every multicellular organism, especially during their development. Among other factors, ECM molecules are necessary for cell migration and also regulate cell differentiation, as could be shown in a wide range of animals. The enteric nervous system (ENS) is built up by neural crest cells (NCC) migrating along predetermined pathways into the developing gut. Studies done for example in mice and chickens did not only enable scientists to reconstruct these routes but also to demonstrate their dependence on ECM molecules such as laminin. Currently we are investigating the influence of different ECM constituents, growth factors and noxious factors on NCC migration and differentiation in the developing chicken gut. The easy handling of the chicken embryo and the use of different methods will give us valuable insights for further investigations.
细胞外基质（ECM）是一个由许多不同大分子组成的网络，在每一个多细胞生物体中都发挥着许多重要功能，尤其是在其发育过程中。在众多因素中，ECM分子对细胞迁移是必需的，并且还能调节细胞分化，这在多种动物中都得到了证实。肠神经系统（ENS）由神经嵴细胞（NCC）沿预定路径迁移至发育中的肠道而形成。例如，在小鼠和鸡身上进行的研究不仅使科学家能够重建这些路径，还能证明它们对诸如层粘连蛋白等ECM分子的依赖性。目前，我们正在研究不同的ECM成分、生长因子和有害因子对发育中的鸡肠道中NCC迁移和分化的影响。鸡胚易于操作以及使用不同的方法将为我们的进一步研究提供有价值的见解。
