Katz-Brull Rachel, Rofsky Neil M, Lenkinski Robert E
Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
Magn Reson Med. 2003 Sep;50(3):461-7. doi: 10.1002/mrm.10560.
The clinical utility of proton MR spectroscopy ((1)H-MRS) has been well demonstrated in the brain, prostate, and breast. The aims of this work were to investigate 1) the feasibility of abdominal and thoracic (1)H-MRS at 3T, 2) the benefits of breathholding to MRS in these regions, and 3) the utility of multiple breathhold averaging for MRS. Breathholding either eliminated or markedly reduced phase and frequency shifts and outer voxel contamination that were associated with the motion of the abdomen and the thorax during breathing. Breathholding was found to be essential to spectroscopic investigation of the thorax. Spectra of renal cell carcinoma metastases in the abdomen and thorax were obtained utilizing multiple breathhold averaging. These spectra exhibited a resonance at 3.2 ppm attributed to the trimethylamine moiety of choline metabolites. The results of this study suggest a practical strategy for implementation of (1)H-MRS in the body.
质子磁共振波谱（（1）H-MRS）在脑、前列腺和乳腺中的临床应用已得到充分证实。本研究的目的是探讨：1）3T场强下腹部和胸部（1）H-MRS的可行性；2）屏气对这些部位MRS的益处；3）多次屏气平均法对MRS的效用。屏气消除或显著减少了与呼吸时腹部和胸部运动相关的相位和频率偏移以及体素外污染。发现屏气对胸部的波谱研究至关重要。利用多次屏气平均法获得了腹部和胸部肾细胞癌转移灶的波谱。这些波谱在3.2 ppm处呈现出一种共振，归因于胆碱代谢物的三甲胺部分。本研究结果提示了在体内实施（1）H-MRS的实用策略。
