Jhaveri Kartik, Guo Lijun, DeVito Timothy
Joint Department of Medical Imaging, University Health Network, University of Toronto, 610 University Ave, 3-957, Toronto ON M5G, Canada.
Joint Department of Medical Imaging, University Health Network, 700 University Ave, Toronto ON M5G, Canada.
Magn Reson Imaging. 2017 Jul;40:12-16. doi: 10.1016/j.mri.2017.03.010. Epub 2017 Mar 31.
To evaluate the feasibility of semi-LASER renal magnetic resonance spectroscopy (MRS) in healthy volunteers and establish signature chemical composition of normal renal tissue towards future application for renal carcinoma characterization and grading.
14 healthy volunteers were recruited after informed consent. Single voxel H spectra were acquired on a 3T MRI system using a semi-LASER sequence, employing outer-volume suppression and VAPOR water suppression with multiple averages in multiple breath-holds. Off-line processing and automatic correction for zero-order phase and frequency using the water resonance or residual water resonance for water-suppressed acquisitions was performed.
11 volunteers successfully completed the entire examination. Phase and frequency correction was necessary to obtain optimal data quality prior to signal summation in few datasets. No lipid resonance was observed in any spectra from the unsuppressed water acquisitions, either in individual transients or in corrected summed spectra opposed to previously reported studies. No signal from other metabolites, such as choline-containing compounds, was observed in any dataset.
Semi-LASER renal MRS is technically feasible. Normal renal parenchyma does not demonstrate detectable levels of lipid or choline. This may provide a reference point for future application of this technique for noninvasive renal carcinoma histologic subtype characterization and grade.
评估半激光肾脏磁共振波谱（MRS）在健康志愿者中的可行性，并确定正常肾组织的标志性化学成分，以便未来用于肾癌的特征描述和分级。
在获得知情同意后招募了14名健康志愿者。使用半激光序列在3T MRI系统上采集单体素H谱，采用体外容积抑制和VAPOR水抑制，并在多次屏气中进行多次平均。对水抑制采集的数据进行离线处理，并使用水共振或残留水共振对零阶相位和频率进行自动校正。
11名志愿者成功完成了全部检查。在少数数据集中，在信号叠加之前需要进行相位和频率校正以获得最佳数据质量。与先前报道的研究相反，在未抑制水采集的任何光谱中，无论是单个瞬态还是校正后的叠加光谱中，均未观察到脂质共振。在任何数据集中均未观察到来自其他代谢物（如含胆碱化合物）的信号。
半激光肾脏MRS在技术上是可行的。正常肾实质未显示出可检测到的脂质或胆碱水平。这可能为该技术未来用于无创性肾癌组织学亚型特征描述和分级提供一个参考点。
