Passowicz-Muszyńska Ewa, Jankowska Renata, Krasnowska Maryla, Gołecki Marcin
Katedra i Klinika Chorób Płuc Akademii Medycznej we Wrocławiu.
Pol Merkur Lekarski. 2003 May;14(83):397-9.
Forty-three patients were enrolled into this study, twenty-eight with sarcoidosis in various radiological stages (I, II, III) and activity of disease (active or non-active) and fifteen with bronchial asthma. Elastase and alpha 1-proteinase inhibitor complex (E-alpha 1IP) concentrations and percentage of neutrophils in broncho-alveolar lavage fluid (BALF) were measured in all groups of patients. There were no significant differences in E-alpha 1IP levels in patients with various activity of sarcoidosis. We noticed significant differences between radiological stages of sarcoidosis. E-alpha 1IP concentration in the pulmonary stage was significantly higher than in stage I hilar adenopathy and stage II hilar adenopathy plus pulmonary opacities. E-alpha 1IP concentrations in BALF were significantly higher in patients with bronchial asthma in comparison to patients with sarcoidosis.
本研究纳入了43例患者，其中28例为处于不同放射学分期（I期、II期、III期）及疾病活动状态（活动期或非活动期）的结节病患者，15例为支气管哮喘患者。对所有患者组支气管肺泡灌洗液（BALF）中的弹性蛋白酶和α1-蛋白酶抑制剂复合物（E-α1IP）浓度以及中性粒细胞百分比进行了测定。结节病不同活动状态患者的E-α1IP水平无显著差异。我们注意到结节病放射学分期之间存在显著差异。肺部受累期的E-α1IP浓度显著高于I期肺门淋巴结肿大期和II期肺门淋巴结肿大伴肺部阴影期。与结节病患者相比，支气管哮喘患者BALF中的E-α1IP浓度显著更高。
