Müzes Györgyi
Semmelweis Egyetem, Altalános Orvostudományi Kar, II. Belgyógyászati Klinika, Budapest.
Orv Hetil. 2003 Jul 20;144(29):1441-6.
Patients with inflammatory bowel disease are likely to develop several extraintestinal complications including skin, eye, joint or liver disorders. Some of them tend to correlate with underlying bowel inflammation or may run a chronic independent course from the bowel disease. Tissue infiltration with lymphocytes seems to be the most prominent feature of extraintestinal manifestations. Recent reports have suggested that these lymphocytes are originally activated in the inflamed bowel and then aberrantly recruited to sites outside the gut. Furthermore the hypothesized existence of an enterohepatic circulation of lymphocytes could also contribute to the pathogenesis of liver complications.
炎症性肠病患者可能会出现多种肠外并发症，包括皮肤、眼睛、关节或肝脏疾病。其中一些并发症往往与潜在的肠道炎症相关，或者可能与肠道疾病呈慢性独立病程。淋巴细胞组织浸润似乎是肠外表现的最显著特征。最近的报告表明，这些淋巴细胞最初在发炎的肠道中被激活，然后异常地募集到肠道外的部位。此外，淋巴细胞肠肝循环的假设存在也可能导致肝脏并发症的发病机制。
