Brescia Morra V, Polverino M, De Luca G, Landi P, Galdi A, Campanella G
Department of Neurology, Second School of Medicine, University of Naples, Italy.
Acta Neurol (Napoli). 1992 Aug-Dec;14(4-6):512-8.
Pulmonary function tests were performed before and at different times after 250 mg L-Dopa in 12 patients with Parkinson's disease (PD). Six were de-novo patients, the other six patients had been taking L-Dopa over different periods. All patients had an abnormal basal flow-volume loop, which significantly improved only in de-novo patients. This improvement occurred early and was independent on improvement of neurological symptoms. The effect of L-Dopa on pulmonary function could be a useful test in differentiating PD from related extrapyramidal syndromes.
对12例帕金森病（PD）患者在服用250mg左旋多巴之前及之后的不同时间进行了肺功能测试。其中6例为初发患者，另外6例患者在不同时间段服用过左旋多巴。所有患者的基础流量-容积环均异常，仅初发患者的该指标有显著改善。这种改善出现得较早，且与神经症状的改善无关。左旋多巴对肺功能的影响可能是鉴别帕金森病与相关锥体外系综合征的一项有用测试。
