Paquot N, Scheen A J
Service de Diabétologie, Nutrition et Maladies métaboliques, Département de Médecine, CHU Sart Tilman, Liège.
Rev Med Liege. 2003 May;58(5):271-4.
It is estimated that 80% of individuals with type 2 diabetes die of cardiovascular diseases. Several factors account for the accelerated atherosclerosis present in diabetic patients. These include hyperglycaemia, dyslipidaemia, hypertension and prothrombotic state. Hypoglycaemic agents, statin or fibrates that improve dyslipidaemia, anti-hypertensive agents, aspirin and healthy lifestyle can modify these factors and have been shown to reduce morbidity and mortality caused by coronary heart disease in diabetic patients. It was recently demonstrated that a multifactorial intervention on modifiable risk factors of cardiovascular disease in type 2 diabetic patients dramatically reduces the incidence of cardiovascular events. Thus, an intensified intervention aimed at multiple risk factors should be recommended in patients with type 2 diabetes.
据估计，2型糖尿病患者中有80%死于心血管疾病。糖尿病患者出现动脉粥样硬化加速有几个因素。这些因素包括高血糖、血脂异常、高血压和血栓前状态。改善血脂异常的降糖药、他汀类药物或贝特类药物、抗高血压药、阿司匹林和健康的生活方式可以改变这些因素，并且已证明可降低糖尿病患者冠心病所致的发病率和死亡率。最近有研究表明，对2型糖尿病患者心血管疾病的可改变危险因素进行多因素干预可显著降低心血管事件的发生率。因此，对于2型糖尿病患者，应建议进行针对多种危险因素的强化干预。
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