Iborra Juan I, Ricos Torrent J V, Monrós Lliso J L, Dumont Martínez R, Casanova Ramón-Borja J, Solsona Narbón E
Instituto Valenciano de Oncología, Servicio de Urología, Valencia, España.
Arch Esp Urol. 1992 Dec;45(10):1001-7.
The results of a double blind prospective study comparing the chemoprophylactic effects of adriamycin and mitomycin C and two modes of instillation (early: 6 hours following transurethral resection; late: 7-14 days later) for superficial carcinoma of the bladder are presented herein. Since the minimum follow up is over 5 years, the effects on tumor progression and mortality achieved by each of the 4 arms of the protocol were also evaluated. Concerning tumor recurrence, early instillation of mitomycin and overall early instillation therapy achieved significantly better results (p < 0.01). No differences, however, were observed relative to tumor progression or mortality.
本文展示了一项双盲前瞻性研究的结果，该研究比较了阿霉素和丝裂霉素C的化学预防效果，以及两种膀胱浅表癌灌注方式（早期：经尿道切除术后6小时；晚期：7 - 14天后）。由于最短随访期超过5年，还评估了方案中4个组各自对肿瘤进展和死亡率的影响。关于肿瘤复发，丝裂霉素早期灌注以及总体早期灌注治疗取得了显著更好的结果（p < 0.01）。然而，在肿瘤进展或死亡率方面未观察到差异。
