皮损内注射干扰素α治疗基底细胞癌：1例报告及文献复习

Treatment of basal cell carcinoma with intralesional interferon alpha: a case report and literature review.

作者信息

McDonald R R, Georgouras K

机构信息

Lidcombe Hospital, NSW.

出版信息

Australas J Dermatol. 1992;33(2):81-6. doi: 10.1111/j.1440-0960.1992.tb00084.x.

DOI:10.1111/j.1440-0960.1992.tb00084.x

PMID:1294057

Abstract

We report the case of a 76 year old man with three ulcerated basal cell carcinomas on his lower limbs. He was considered unsuitable for surgical therapy and was treated by intralesional interferon alpha-2b (Intron A) injections. Twenty months post therapy two of the three treatment sites remain clinically cured. Recurrence occurred at the site which received the smallest total dose of interferon. A review of the therapeutic trials of interferon alpha for basal cell carcinoma is presented. We conclude that interferon alpha-2b is a useful agent for treatment of basal cell carcinoma in selected patients.

摘要

我们报告了一例76岁男性患者，其下肢有三处溃疡型基底细胞癌。他被认为不适合手术治疗，遂接受了病灶内注射干扰素α-2b（安福隆）治疗。治疗后20个月，三个治疗部位中的两个在临床上保持治愈状态。复发发生在接受干扰素总剂量最小的部位。本文对干扰素α治疗基底细胞癌的治疗试验进行了综述。我们得出结论，干扰素α-2b对特定患者的基底细胞癌治疗是一种有用的药物。