Katopodis Kostas P, Koliousi Elli L, Andrikos Emilios K, Pappas Michael V, Elisaf Moses S, Siamopoulos Kostas C
Department of Internal Medicine, Division of Nephrology, University Hospital of Ioannina, Ioannina, Greece.
Artif Organs. 2003 Sep;27(9):853-7. doi: 10.1046/j.1525-1594.2003.07193.x.
We carried out this retrospective study to examine the magnesium status of our chronic ambulatory peritoneal dialysis (CAPD) patients dialyzed with 0.75 mmol/L (group I) or 0.50 mmol/L (group II) magnesium peritoneal dialysis solution. A total of 34 anuric patients on CAPD (age:31-72 years; duration of CAPD:7-74 months) were studied. None of them received magnesium-containing phosphate binders or vitamin D. Biochemical parameters including magnesium, calcium, phosphate, parathormone, and albumin were measured in all patients. The corrected for hypoalbuminemia serum magnesium concentration in group I was significantly higher compared to that found in group II. However, there were no significant differences in the other measured parameters between the two groups of CAPD patients, though iPTH levels were somewhat increased in group II patients. Serum magnesium levels were weakly correlated with serum prealbumin levels in both groups of CAPD patients (r=0.16, P=0.08 and r=0.17, P=0.07). The incidence of hypermagnesemia was significantly higher in group I patients versus those in group II (13/19 68.4%] vs. 2/15 13.3%], P<0.01). On the other hand, no patient developed hypomagnesemia (corrected total magnesium <0.65 mmol/L), despite the trend toward decreased magnesium levels in group II patients. Our results point out that serum iPTH levels and nutritional parameters, such as prealbumin levels, should be taken into account in the choice of the magnesium concentration of the peritoneal dialysis fluid.
我们开展了这项回顾性研究，以检测接受0.75 mmol/L（I组）或0.50 mmol/L（II组）镁浓度腹膜透析液透析的慢性非卧床腹膜透析（CAPD）患者的镁状态。共研究了34例接受CAPD的无尿患者（年龄：31 - 72岁；CAPD病程：7 - 74个月）。他们均未接受含镁的磷结合剂或维生素D。对所有患者测量了包括镁、钙、磷、甲状旁腺激素和白蛋白在内的生化参数。I组经低白蛋白血症校正后的血清镁浓度显著高于II组。然而，两组CAPD患者的其他测量参数并无显著差异，尽管II组患者的iPTH水平有所升高。两组CAPD患者的血清镁水平与血清前白蛋白水平均呈弱相关（r = 0.16，P = 0.08；r = 0.17，P = 0.07）。I组患者高镁血症的发生率显著高于II组（13/19 [68.4%] 对 2/15 [13.3%]，P < 0.01）。另一方面，尽管II组患者有镁水平下降的趋势，但无患者发生低镁血症（校正后总镁 < 0.65 mmol/L）。我们的结果指出，在选择腹膜透析液的镁浓度时，应考虑血清iPTH水平和营养参数，如前白蛋白水平。
