用于放射性核素治疗的177镥的生产物流

Production logistics of 177Lu for radionuclide therapy.

作者信息

Pillai M R A, Chakraborty Sudipta, Das Tapas, Venkatesh Meera, Ramamoorthy N

机构信息

Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai 400 085, India.

出版信息

Appl Radiat Isot. 2003 Aug-Sep;59(2-3):109-18. doi: 10.1016/s0969-8043(03)00158-1.

DOI:10.1016/s0969-8043(03)00158-1

PMID:12941498

Abstract

Owing to its favourable decay characteristics 177Lu [T(1/2)=6.71 d, Ebeta(max)=497 keV] is an attractive radionuclide for various therapeutic applications. Production of 177Lu using [176Lu (n,gamma)177Lu] reaction by thermal neutron bombardment on natural as well as enriched lutetium oxide target is described. In all, approximately 4 TBq/g (108 Ci/g) of 177Lu was obtained using natural Lu target after 7 d irradiation at 3 x 10(13) n/cm2/s thermal neutron flux while it was approximately 110 TBq/g (3000 Ci/g) of 177Lu when 60.6% enriched 176Lu target was used. In both the cases, radionuclidic purity was approximately 100%, only insignificant quantity of 177mLu [T(1/2)=160.5 d, Ebeta(max)=200 keV] could be detected as the radionuclidic impurity. Production logistics using different routes of production is compared. Possible therapeutic applications of 177Lu are discussed and its merits highlighted by comparison with other therapeutic radionuclides.

摘要

由于其良好的衰变特性，177镥（半衰期T(1/2)=6.71天，最大β能量Eβ(max)=497千电子伏特）是一种适用于各种治疗应用的有吸引力的放射性核素。本文描述了通过热中子轰击天然以及富集氧化镥靶材，利用[176镥(n,γ)177镥]反应生产177镥的过程。使用天然镥靶材在热中子通量为3×10¹³ 中子/厘米²/秒的条件下辐照7天后，总共获得了约4太贝克勒尔/克（108居里/克）的177镥；而使用富集度为60.6%的176镥靶材时，获得的177镥约为110太贝克勒尔/克（3000居里/克）。在这两种情况下，放射性核素纯度均约为100%，仅能检测到极少量的177m镥（半衰期T(1/2)=160.5天，最大β能量Eβ(max)=200千电子伏特）作为放射性核素杂质。比较了使用不同生产路线的生产物流情况。讨论了177镥可能的治疗应用，并通过与其他治疗性放射性核素比较突出了其优点。