Chakraborty Sudipta, Unni P R, Venkatesh Meera, Pillai M R A
Chemistry Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai 400 085, India.
Appl Radiat Isot. 2002 Sep;57(3):295-301. doi: 10.1016/s0969-8043(02)00100-8.
Owing to its favourable decay characteristics 175Yb (T1/2 = 4.2 d, E beta(max) = 480 keV) can be regarded as a potential radionuclide for therapeutic applications. Production of 175Yb using (174Yb(n, gamma)175Yb) reaction by thermal neutron bombardment on natural ytterbium target is described. The activity of 175Yb produced as well as its radionuclidic purity under different irradiation conditions were determined by gamma-ray spectrometry using an HPGe 4 K MCA system and compared with theoretically calculated values. The radiochemical purity after chemical processing was determined by paper chromatography as well as paper electrophoresis techniques. It is found that 31 Ci/g (1145 GBq/g) of 175Yb can be produced with > 95% radionuclidic purity (with approximately 3% of 169Yb and approximately 2% of 177Lu) by irradiating natural Yb2O3 target at a thermal neutron flux of 3 x 10(13) n/cm2/s for a period of 5 d.
由于其良好的衰变特性，175镱（半衰期T1/2 = 4.2天，最大β能量Eβ(max) = 480 keV）可被视为一种潜在的治疗用放射性核素。本文描述了通过热中子轰击天然镱靶利用（174镱（n，γ）175镱）反应生产175镱的过程。使用HPGe 4 K MCA系统通过γ射线能谱法测定了在不同辐照条件下产生的175镱的活度及其放射性核素纯度，并与理论计算值进行了比较。化学处理后的放射化学纯度通过纸色谱法和纸电泳技术测定。结果发现，通过在3×10(13) n/cm2/s的热中子通量下辐照天然Yb2O3靶5天，可以生产出放射性核素纯度> 95%（约含3%的169镱和约2%的177镥）的175镱，活度为31 Ci/g（1145 GBq/g）。
