Comparison of methods for preparation of 125I brachytherapy source cores for the treatment of eye cancer.

Two procedures for fixing the 125I activity on different matrices were explored. In the first method, anodic deposition of 125I on silver wire was used. In the second, 125I was adsorbed as iodate (IO3-) on alumina microspheres by using a solid-solution interface technique. While the 125I uptake was approximately 84% on the silver wires by electrodeposition method, the microspheres showed approximately 97% by the solid-solution interface technique. The low leachable (0.05%) wires, and comparatively high leachable (approximately 4%) spheres were trial encapsulated and laser welded. The encapsulated sources were measured for source strength and were found to be suitable for the treatment of eye cancer.