胎儿性别对孕早期静脉导管血流的影响。

Effect of fetal gender on first-trimester ductus venosus blood flow.

作者信息

Prefumo F, Venturini P L, De Biasio P

机构信息

U. O. di Ostetricia e Ginecologia, Istituto G. Gaslini, University of Genoa, Genoa, Italy.

出版信息

Ultrasound Obstet Gynecol. 2003 Sep;22(3):268-70. doi: 10.1002/uog.205.

DOI:10.1002/uog.205

PMID:12942499

Abstract

OBJECTIVES

Recent reports have suggested that nuchal translucency (NT) measurements in the first trimester may be influenced by fetal gender. Since both NT and central venous blood flow are considered to be related to fetal cardiac function, we investigated gender-related differences in first-trimester ductus venosus Doppler indices.

METHODS

A total of 73 male and 79 female normal fetuses at 10-14 weeks of gestation were included in the study. The pulsatility index for veins (PIV), peak velocity during ventricular systole (S-wave), time-averaged maximum velocity (TAMV) and A-wave velocity (A-wave) were recorded in each case and converted to the corresponding Z-scores.

RESULTS

The mean Z-score values of PIV, S-wave and TAMV were significantly lower in male fetuses compared to female fetuses (P < 0.01 for all three indices). By contrast, A-wave velocities were not different in the two groups. The correlation between S-wave velocity and TAMV was significant in both male (P < 0.001) and female (P < 0.001) fetuses, while PIV did not appear to be related to TAMV either in males (P = 0.90) or in females (P = 0.49). A-wave velocity had a significant negative correlation with PIV in both groups. Finally, PIV was significantly correlated with S-wave velocity in female fetuses (P < 0.01) but not in males (P = 0.14).

CONCLUSION

These findings suggest that early cardiovascular development may be different in male and female fetuses.

摘要

目的

最近的报告表明，孕早期的颈部透明带（NT）测量值可能受胎儿性别的影响。由于NT和中心静脉血流都被认为与胎儿心脏功能有关，我们研究了孕早期静脉导管多普勒指数的性别相关差异。

方法

本研究纳入了73例男性和79例女性正常胎儿，孕周为10 - 14周。记录每例胎儿的静脉搏动指数（PIV）、心室收缩期峰值速度（S波）、时间平均最大速度（TAMV）和A波速度（A波），并将其转换为相应的Z分数。

结果

与女性胎儿相比，男性胎儿的PIV、S波和TAMV的平均Z分数值显著更低（所有三个指数P < 0.01）。相比之下，两组的A波速度没有差异。S波速度与TAMV之间的相关性在男性（P < 0.001）和女性（P < 0.001）胎儿中均显著，而PIV在男性（P = 0.90）或女性（P = 0.49）中似乎与TAMV均无关。两组中A波速度与PIV均呈显著负相关。最后，PIV在女性胎儿中与S波速度显著相关（P < 0.01），但在男性胎儿中不相关（P = 0.14）。