Teixeira L S, Leite J, Viegas M J B C, Faria M M L, Chaves A S, Teixeira R C, Pires M C, Pettersen H
Pós-Graduação em Saúde da Mulher, Faculdade de Medicina, Belo Horizonte, Minas Gerais, Brazil.
Ultrasound Obstet Gynecol. 2008 Mar;31(3):261-5. doi: 10.1002/uog.5245.
To establish reference curves for ductus venosus blood flow velocities during the first trimester and compare them with previously published curves.
This was a cross-sectional and retrospective study performed between January 1998 and January 2003. The following inclusion criteria were used: singleton pregnancy, velocity measurements taken when the crown-rump length (CRL) was between 34 and 84 mm, absence of fetal anomalies, full-term pregnancy and newborn birth weight appropriate for gestational age. The following variables of the ductus venosus were measured: peak velocity during ventricular systole (S-wave) and diastole (D-wave), nadir during atrial contraction in late diastole (A-wave), time-averaged maximum velocity (TAMXV) and pulsatility index for veins (PIV).
A total of 843 fetuses were included. The mean CRL was 62 (range, 34-84) mm. The S-wave, D-wave, TAMXV and PIV were normally distributed, and logarithmic transformation was performed to achieve a normal distribution for the A-wave. S-wave, D-wave and A-wave and TAMXV increased with CRL. PIV increased up to a CRL of 63 mm and decreased thereafter. Regression analysis revealed a significant quadratic relationship between PIV and CRL.
S-wave, D-wave, A-wave velocities and TAMXV in the ductus venosus increase with CRL between 34 and 84 mm. The reference range for PIV has a biphasic pattern, with an initial non-significant increase up to a CRL of 63 mm and a fall thereafter.
建立孕早期静脉导管血流速度的参考曲线，并与先前发表的曲线进行比较。
这是一项于1998年1月至2003年1月进行的横断面回顾性研究。采用以下纳入标准：单胎妊娠、在头臀长（CRL）为34至84毫米时进行速度测量、无胎儿畸形、足月妊娠且新生儿出生体重与孕周相符。测量静脉导管的以下变量：心室收缩期峰值速度（S波）和舒张期峰值速度（D波）、舒张末期心房收缩期最低点速度（A波）、时间平均最大速度（TAMXV）和静脉搏动指数（PIV）。
共纳入843例胎儿。平均CRL为62（范围34 - 84）毫米。S波、D波、TAMXV和PIV呈正态分布，对A波进行对数转换以使其呈正态分布。S波、D波、A波和TAMXV随CRL增加。PIV在CRL达到63毫米之前升高，之后降低。回归分析显示PIV与CRL之间存在显著的二次关系。
静脉导管中S波、D波、A波速度和TAMXV在CRL为34至84毫米之间随CRL增加。PIV的参考范围呈双相模式，在CRL达到63毫米之前最初无显著升高，之后下降。
