Veriasova N N, Polysalov V N, Tarazov P G
Vestn Khir Im I I Grek. 2003;162(3):22-6.
During the period from 1989 till 1998 local ethanol injection therapy (LEIT) was used in treatment of 37 patients aged 39-78. The multiple focused form of hemangioma of the liver was observed in 15 (41%) patients, solitary in 20 (54%), the diffuse-focused in 2 (5%) patients. The distribution of the tumors according to the histological structure was as follows: cavernous hemangioma in 22 (60%) patients, capillary--in 2 (5%) patients, mixed in 13 (35%). Local injection therapy was the only method of treatment of 17 patients. In 13 patients this method gave insufficiently effective embolization of the hepatic artery, in 2 patients the injection therapy was combined with ligation of the hepatic artery and in 5 patients--with resection of the liver because of another tumor. The volume of a single use of ethanol varied from 6 to 60 ml. Long-term results were followed-up during 3-6 years. By the data of USI, CT, NMR in all the patients there were changes in the tumor typical of fibrosis. Positive results of the treatment such as a reduced size of hemangioma were noted in 27 patients (73.0%), pains disappeared in 10 out of 29 patients (35%) who had pain syndrome. A conclusion is made that local ethanol injection therapy with 96% ethyl alcohol is effective in treatment of hemangioma of the liver. It gives good long-term results including a combination with the endovascular treatment and resection of the liver.
1989年至1998年期间，采用局部乙醇注射疗法（LEIT）治疗了37例年龄在39至78岁之间的患者。观察到15例（41%）患者为肝脏血管瘤的多发聚焦型，20例（54%）为单发，2例（5%）为弥漫聚焦型。根据组织学结构，肿瘤分布如下：海绵状血管瘤22例（60%），毛细血管型2例（5%），混合型13例（35%）。局部注射疗法是17例患者的唯一治疗方法。13例患者中，该方法对肝动脉的栓塞效果不佳；2例患者的注射疗法与肝动脉结扎相结合；5例患者因其他肿瘤而行肝脏切除术。单次使用乙醇的量为6至60毫升。随访3至6年观察长期疗效。根据超声成像（USI）、计算机断层扫描（CT）、核磁共振（NMR）的数据，所有患者的肿瘤均出现了典型的纤维化改变。27例患者（73.0%）出现了如血管瘤体积缩小等治疗阳性结果，29例有疼痛综合征的患者中，10例（35%）疼痛消失。得出结论：用96%乙醇进行局部乙醇注射疗法对肝脏血管瘤治疗有效。该方法能取得良好的长期疗效，包括与血管内治疗及肝脏切除术联合使用。
